JBJ-07-149 - CAS 2140807-58-3

JBJ-07-149 is an inhibitor of EGFRL858R/T790M with an IC50 of 1.1 nM. It suppresses the proliferation of Ba/F3 cells with IC50 values of 4.9 μM when used alone, and 0.148 μM when combined with Cetuximab. Additionally, JBJ-07-149 can serve as a target protein ligand for synthesizing [DDC-01-163].

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2140746

C28H26N6O2S

510.61

O=C1C2=CC(=CC=C2CN1C(C(=O)NC3=NC=CS3)C=4C=CC=CC4)C=5C=NC(=CC5)N6CCNCC6

-20°C

Ice Packs

Small Compound