JBJ-08-178-01 - CAS 2401867-58-9

JBJ-08-178-01, a mutant-selective tyrosine kinase inhibitor, targets (HER2) human epidermal growth factor receptor 2 and exhibits antitumoral activity. This compound not only diminishes HER2's kinase activity and protein levels through the induction of proteasomal degradation of the receptor but also shows promise in non-small-cell lung cancer research.

Others, Proteasome

Ubiquitination, Others, Proteases/Proteasome

2401800

C31H30N8O3

562.62

N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CC1C#N)C3=CC(C)=C(OC4=CC=5N(C=C4)N=CN5)C=C3

-20°C

Ice Packs

Small Compound