JC2-11 - CAS 937820-89-8

JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.

NOD-like Receptor (NLR), AIM2, IL Receptor, Caspase, Dehydrogenase, ROS

Immunology/Inflammation, Metabolism, Apoptosis, Proteases/Proteasome

937723

0.9988

C17H15FO4

302.3

C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2

-20°C

Ice Packs

Small Compound