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Molfinity

JGB1741 - CAS 1256375-38-8

JGB1741 - CAS 1256375-38-8

MF-0093250-01

$50.37 USD
$50.37 USD
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Product Details

  • Bioactivity

    JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies.

  • Target

    Apoptosis, Sirtuin

  • Related Pathways

    Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair

  • CAS Number

    1256329

  • Purity

    0.9986

  • Molecular Formula

    C27H24N2O2S

  • Molecular Weight

    440.56

  • SMILES

    Oc1ccc2ccccc2c1\C=N\c1sc2CCCCc2c1C(=O)NCc1ccccc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound