JH-131e-153 - CAS 742104-91-2

JH-131e-153, a diacylglycerol (DAG) -lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound's C1 domain shares sequence and structure homology with protein kinase C (PKC), with an activation preference of PKCα>Munc13-1>PKCε. JH-131e-153 is implicated in the modulation of neuronal processes and holds potential for research in neurodegenerative diseases [1].

Others, PKC

Cytoskeletal Signaling, Chromatin/Epigenetic, Others

742104-91-2

C22H38O5

382.53

C(OC(C(C)(C)C)=O)[C@]1(CO)C\C(=C\CC(CC(C)C)CC(C)C)\C(=O)O1

-20°C

Ice Packs

Small Compound