1 1

Molfinity

JH-RE-06 - CAS 1361227-90-8

JH-RE-06 - CAS 1361227-90-8

MF-0033078-01

$39.15 USD
$39.15 USD
Sale Sold out
Taxes included.
Size
View full details

Product Details

  • Bioactivity

    JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.

  • Target

    DNA/RNA Synthesis

  • Related Pathways

    DNA Damage/DNA Repair, Cell Cycle/Checkpoint

  • CAS Number

    1361129

  • Purity

    0.9929

  • Molecular Formula

    C20H16Cl3N3O4

  • Molecular Weight

    468.72

  • SMILES

    CC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound