JI6 - CAS 856436-16-3

JI6 (JAK3 Inhibitor VI) is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia.

JAK, FLT, c-Kit

Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, Stem Cells, Tyrosine Kinase/Adaptors

856417

0.9864

C19H17N3O4S

383.42

CS(=O)(O)=O.O=C(/C1=C\C2=CC=CN2)NC(C=C3)=C1C=C3C4=CN=CC=C4

-20°C

Ice Packs

Small Compound