(-) -JJ-450 - CAS 1998094-23-7

(-) -JJ-450 is a non-competitive antagonist targeting the androgen receptor (AR) . It is more effective than (+) -JJ-450 in inhibiting androgen-induced AR activity, while (+) -JJ-450 inhibits AR via a mechanism distinct from Enzalutamide (MDV3100), possibly targeting the ligand-binding domain (LBD) of AR. (-) -JJ-450 inhibits transcriptional activity of both wild-type AR and the mutant ARF876L by suppressing AR nuclear translocation and promoting intranuclear degradation of unbound AR. This compound can be utilized in research focusing on castration-resistant prostate cancer (CRPC) that is resistant to Enzalutamide.

Androgen Receptor

Endocrinology/Hormones

1998064

C21H22ClFN2O

372.86

C(=O)([C@@H]1[C@@H](C1)C2=CC=C(F)C=C2)N3CCN(CC3)C4=C(C)C=CC(Cl)=C4

-20°C

Ice Packs

Small Compound