JJO-1 - CAS 16722-44-4

JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs among other known direct activators of AMPK in that allosteric activation occurs only at low ATP concentrations, and is not influenced by either mutation of the γ subunit adenylate-nucleotide binding sites or deletion of the β subunit carbohydrate-binding module.

Others, AMPK

PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, Others

16674

C19H13N3

283.33

N(=CC1=NC2=C(C=C1)C=CC=C2)C3=CC4=C(N=C3)C=CC=C4

-20°C

Ice Packs

Small Compound