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Molfinity

JKE-1674 - CAS 2421119-60-8

JKE-1674 - CAS 2421119-60-8

MF-0093875-01

$42.89 USD
$42.89 USD
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Product Details

  • Bioactivity

    JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.

  • Target

    GPX, Glutathione Peroxidase, Ferroptosis

  • Related Pathways

    Metabolism, Oxidation-Reduction, Apoptosis

  • CAS Number

    2421051

  • Purity

    0.9872

  • Molecular Formula

    C20H20Cl2N4O4

  • Molecular Weight

    451.3

  • SMILES

    O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound