JMI-105 - CAS 2227315-30-0

JMI-105 has the potential as an antimalarial agent. JMI-105 is a potent inhibitor of Plasmodium falciparum falcipain-2 protease (PfFP-2) that inhibits the P. falciparum strains CQ S (3D7) and CQ R (RKL-9) growth with IC 50 values of 8.8 μM and 14.3 μM. In a murine model with P. berghei ANKA infection, JMI-105 significantly decreases parasitemia and prolonged host survival [1].

Parasite, Others

Microbiology/Virology, Others

2227285

C20H23N3O2

337.42

C(OC1=CC(C(C)C)=CC=C1C)C2=CN(N=N2)C3=CC=C(OC)C=C3

-20°C

Ice Packs

Small Compound