JMJD3/HDAC-IN-1 - CAS 2883046-06-6

Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone deacetylase, IC50 = 16 nM) . It induces hypermethylation of histone H3K27 and hyperacetylation of H3K9, while also promoting apoptosis through the cleavage of caspase-7 and PARP. This compound has demonstrated the ability to effectively inhibit cancer cell cloning, migration, and invasion [1].

HDAC, Apoptosis, Histone Demethylase

Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair

2883046-06-6

C21H30N6O2

398.5

N(CCCCCC(NO)=O)C=1N=C(N=C(C1)N2CCCCCC2)C3=CC=CC=N3

-20°C

Ice Packs

Small Compound