JMV 449 - CAS 139026-66-7

Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum) . Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.

Neurotensin Receptor

GPCR/G Protein

138953

C38H66N8O7

746.96

C([C@@H](NC[C@H](CCCCN)N)CCCCN)(=O)N1[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@H](CC)C)=O)=O)CCC1

-20°C

Ice Packs

Peptide