JNJ-1013 - CAS 2597343-08-1

JNJ-1013 is a potent and selective IRAK1 degrader, with IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases cleaved PARP expression, and decreases the expression of IRAK1, p-IKBα, and pSTAT3 (Tyr705) [1].

STAT, PARP, IRAK, PROTACs, Apoptosis

DNA Damage/DNA Repair, PROTAC, JAK/STAT signaling, Apoptosis, Stem Cells, Immunology/Inflammation, Chromatin/Epigenetic, NF-κB

2597343-08-1

0.99596

C46H55N9O7S

878.05

C([C@@H](NC(COC1CCN(CC1)C2=CC(OC)=C(NC(=O)C=3N=C(C=CC3)C=4C=CNN4)C=C2)=O)C(C)(C)C)(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5

-20°C

Ice Packs

Small Compound