JNJ-9676 - CAS 3026520-19-1

JNJ-9676 is an orally active inhibitor of the coronavirus membrane protein, which binds to the membrane protein dimer's transmembrane domain-formed binding pocket, thereby blocking viral assembly and release. It exhibits nanomolar-level antiviral activity against the novel coronavirus and SARS-CoV.

DNA/RNA Synthesis, SARS-CoV

Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Microbiology/Virology

3026500

0.9993

C28H21F2N5O2

497.5

C(NC1=CC(C#N)=CC=C1)(=O)C2=C3N(C[C@H](C)N(C3=O)C4=CC=C(C(F)(F)C5=CC=CC=C5)C=C4)N=C2

-20°C

Ice Packs

Small Compound