JNJ-pan-AR - CAS 1332390-06-3

JNJ-pan-AR, a meylated analogue of JNJ-63576253, is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L. JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.

Others

Others

1332390-06-3

C25H24F3N5O2S

515.55

O=C1C2(N(C(=S)N1C=3C=C(C(F)(F)F)C(C#N)=NC3)C4=CC=C(OC5CCN(C)CC5)C=C4)CCC2

-20°C

Ice Packs

Small Compound