JNK-1-IN-4 - CAS 3047795-60-5

JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA) . JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.

JNK

MAPK

3047730

C22H25BrN6O3

501.38

O=C(N)C1=CC(OCCN(C)C)=CC=C1NC2=NC(=NC=C2Br)NC3=CC=C(OC)C=C3

-20°C

Ice Packs

Small Compound