JNK-IN-23 - CAS 1007786-48-2

JNK-IN-23 (Compound K12) is an inhibitor of JNK. It effectively inhibits the proliferation of MDA-MB-231 cells with a GIC50 of 30 nM. In vivo, JNK-IN-23 blocks metastatic growth of triple-negative breast cancer (TNBC) . Additionally, it suppresses the growth of lung metastases by dual targeting of glutaminase-1 (GLS) and the pyruvate dehydrogenase complex (PDHC) .

JNK

MAPK

1007736

C19H18N4OS2

382.5

O=C1N=C(NC=2SC(=C(C12)C)C)C(SC=3N=C4C=CC=CC4=NC3C)C

-20°C

Ice Packs

Small Compound