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Molfinity

JP-153 - CAS 1802937-26-3

JP-153 - CAS 1802937-26-3

MF-0114475-01

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Product Details

  • Bioactivity

    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.

  • Target

    FAK, Src

  • Related Pathways

    Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis

  • CAS Number

    1802908

  • Molecular Formula

    C21H19NO5

  • Molecular Weight

    365.379

  • SMILES

    O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound