JPS016 - CAS 2669785-77-5

JPS016, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC) . It serves as a potent HDAC1/2 degrader, resulting in a significant increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].

PROTACs, Others, HDAC

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair, PROTAC

2669703

C48H63N7O8S

898.12

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCCCCCOCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)C(C)(C)C)cc1

-20°C

Ice Packs

PROTAC