JPS035 - CAS 2669785-84-4

JPS035, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), effectively degrades class I histone deacetylase (HDAC), specifically HDAC1/2. Its potent activity is associated with an increase in differentially expressed genes and enhanced apoptosis in HCT116 cells [1].

PROTACs, Others, HDAC

DNA Damage/DNA Repair, Others, PROTAC, Chromatin/Epigenetic

2669697

C49H65N7O7S

896.15

CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1OCCCCCCCCCCCC(=O)Nc1ccc(cc1)C(=O)Nc1ccccc1N)-c1scnc1C)C(C)(C)C

-20°C

Ice Packs

PROTAC