JPS036 - CAS 2669785-85-5

JPS036, a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC), efficiently degrades class I histone deacetylase (HDAC), particularly HDAC1/2. Its activity results in a substantial increase in differentially expressed genes and promotes enhanced apoptosis in HCT116 cells [1].

PROTACs, Others, HDAC

Others, PROTAC, DNA Damage/DNA Repair, Chromatin/Epigenetic

2669695

C51H66FN7O7S

940.18

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCCCCCCCCCCC(=O)Nc2ccc(cc2)C(=O)Nc2ccccc2N)c1

-20°C

Ice Packs

PROTAC