JS25 - CAS 2411771-95-2

JS25 is a selective, covalent BTK inhibitor that deactivates BTK by chelating Tyr551, exhibiting an IC50 of 5.8 nM. It suppresses cancer cell proliferation, induces pronounced cell death, and enhances Burkitt's lymphoma murine xenograft model outcomes. Importantly, JS25 efficiently penetrates the blood-brain barrier.

BTK, Others

Tyrosine Kinase/Adaptors, Others, Angiogenesis

2411674

C29H24N4O4S

524.59

O=C1N(C2=C3C(C=C(C=C3)C4=CC=C(NS(C)(=O)=O)C=C4)=NC=C2C=C1)C5=CC(NC(C=C)=O)=CC(C)=C5

-20°C

Ice Packs

Small Compound