JT002 - CAS 2238820-43-2

JT002 is an orally active NLRP3 inflammasome inhibitor that decreases the production of NLRP3-dependent proinflammatory cytokines (such as IL-1β, IL-1α, IL-18) and pyroptosis, as well as inhibits the formation of the NLRP3 inflammasome complex. Additionally, JT002 mitigates airway hyperresponsiveness and airway neutrophilia in mice [1].

NOD-like Receptor (NLR)

Immunology/Inflammation

2238775

C20H24N4O5S

432.49

N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](OC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4

-20°C

Ice Packs

Small Compound