JTE-952 - CAS 1255303-54-8

JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.

C-Fms, Histamine Receptor

Neuroscience, GPCR/G Protein, Tyrosine Kinase/Adaptors, Immunology/Inflammation

1255241

C30H34N2O6

518.6

C(=O)(N1CC(C1)C2=CC(OC)=C(OCC3=CC=C(C=C3)C4CC4)C=C2)C5=CC(COC[C@H](CO)O)=CC=N5

-20°C

Ice Packs

Small Compound