JTP-4819 - CAS 162203-65-8

JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentrations, it inhibited the degradation of substance P, arginine-vasopressin, and thyrotropin-releasing hormone by PEP in supernatants of the rat cerebral cortex and hippocampus. Repeated administration of JTP-4819 reversed the aging-induced decrease in brain substance P-like and thyrotropin-releasing hormone-like immunoreactivity, suggesting it may improve the imbalance of peptidergic neuronal systems that develops with senescence by inhibiting PEP activity. Additionally, JTP-4819 increased acetylcholine release from the frontal cortex and hippocampus, regions closely associated with memory, in both young and aged rats.

Others, Prolyl Endopeptidase (PREP)

Proteases/Proteasome, Others, Metabolism

162130

C19H25N3O4

359.42

C(=O)([C@H]1N(C(NCC2=CC=CC=C2)=O)CCC1)N3[C@H](C(CO)=O)CCC3

-20°C

Ice Packs

Small Compound