JTT-553 - CAS 701232-94-2

JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG) . JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-α mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM) .

Acyltransferase

Metabolism

701136

C25H27F3N4O3

488.5

C(C(O)=O)[C@H]1CC[C@]2(C=3C(CC2)=CC(=CC3)C4=NC=5C(OC4(C)C)=NC(C(F)(F)F)=NC5N)CC1

-20°C

Ice Packs

Small Compound