Juglone - CAS 481-39-0

Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM) . Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.

NF-κB, Apoptosis, TLR, DNA/RNA Synthesis, Antibacterial

NF-κB, DNA Damage/DNA Repair, Microbiology/Virology, Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint

442

0.9924

C10H6O3

174.15

Oc1cccc2C(=O)C=CC(=O)c12

-20°C

Ice Packs

Natural Product