JV8 - CAS 2841716-61-6

JV8 is a BRD4 PROTAC degrader that facilitates ubiquitination and degradation of BRD4, inducing apoptosis (Apoptosis) . It exhibits antitumor activity in a mouse 4T1 orthotopic tumor model.

Epigenetic Reader Domain

Chromatin/Epigenetic

2841649

C50H62ClN9O8S2

1016.67

CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC(N[C@@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC