JWJ-01-306 - CAS 3069975-17-0

JWJ-01-306 is a molecular glue that targets the C2H2 zinc finger transcription factor ZBTB11. It effectively degrades ZBTB11, reduces oxidative phosphorylation (OXPHOS) and the tricarboxylic acid (TCA) cycle, and inhibits the proliferation of KAS-resistant PDAC cells. In mouse models, JWJ-01-306 demonstrates favorable pharmacokinetic properties.

Molecular Glues

PROTAC

3069958

C28H26ClF3N4O4

574.98

O=C1C=C(NC2=CC=CC(=C2)C3(NCCC4=CC=C(Cl)C(=C4)C(F)(F)F)CCC3)C(=O)N1C5C(=O)NC(=O)CC5

-20°C

Ice Packs

PROTAC