K-252a - CAS 99533-80-9

K-252a is a protein kinase inhibitor targeting serine-threonine, tyrosine, and CAM kinases. In vitro, it blocks NGF-induced TrkA signalling and neural differentiation, exhibiting antitumour, antibacterial, anti-inflammatory, and neuroprotective activities.

PKC, PKA, Autophagy, Serine/threonin kinase, CaMK, Apoptosis, Antibiotic, Trk receptor, Tyrosinase

Chromatin/Epigenetic, Autophagy, Cell Cycle/Checkpoint, Neuroscience, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Apoptosis, Microbiology/Virology, Metabolism, Proteases/Proteasome

99444

C27H21N3O5

467.47

C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@]2(C(OC)=O)O)[H])=CC=CC8

-20°C

Ice Packs

Natural Product