K-Ras ligand-Linker Conjugate 3 - CAS 2378261-87-9

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP) . This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

Others, Target Protein Ligand-Linker Conjugate

PROTAC, Others

2378165

C49H65N7O10S

944.15

O(C[C@@H]1C[C@@H](OCCOCCOCCOCCOS(=O)(=O)C2=CC=C(C)C=C2)CN1C)C3=NC(=C4C(CN(CC4)C=5C6=C(C=CC5)C=CC=C6)=N3)N7C[C@H](CC#N)N(C(OC(C)(C)C)=O)CC7

-20°C

Ice Packs

PROTAC