K-Ras ligand-Linker Conjugate 4 - CAS 2378261-83-5

K-Ras ligand-Linker Conjugate 4 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker, responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It has the potential to be used in synthesizing PROTAC K-Ras Degrader-1, which shows a degradation efficacy of ≥70% in SW1573 cells[1].

Target Protein Ligand-Linker Conjugate, Others

Others, PROTAC

2378173

C35H51N7O8

697.82

O(C[C@@H]1C[C@@H](OCCOCCOCCOCCO)CN1C)C2=NC(=C3C(=N2)CNCC3)N4C[C@H](CC#N)N(C(OCC5=CC=CC=C5)=O)CC4

-20°C

Ice Packs

PROTAC