K-Ras ligand-Linker Conjugate 5 - CAS 2378261-85-7

K-Ras ligand-Linker Conjugate 5 is a chemical compound combining a K-Ras recruiting ligand with a PROTAC linker for E3 ligases, such as VHL, CRBN, MDM2, and IAP. This conjugate is crucial for synthesizing PROTAC K-Ras Degrader-1, displaying a degradation efficacy of ≥70% in SW1573 cells [1].

Others, Target Protein Ligand-Linker Conjugate

PROTAC, Others

2378169

C42H59N7O8

789.96

CN1C[C@@H](C[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)OC(C)(C)C)c1cccc2ccccc12)OCCOCCOCCOCCO

-20°C

Ice Packs

PROTAC