K777 - CAS 233277-99-1

K777 is a potent, orally active, and irreversible inhibitor of cysteine protease, functioning as a potent CYP3A4 inhibitor (IC50 = 60 nM) and a selective CCR4 antagonist, which inhibits chemotaxis. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypanosoma cruzi, and cathepsins B and L, targeting cathepsin-mediated cell entry and exhibiting broad-spectrum antiviral activity. It inhibits EBOV and SARS-CoV pseudovirus entry with IC50 values of 0.87 nM and 0.68 nM, respectively.

SARS-CoV, CCR, Cysteine Protease, Parasite, Cytochromes P450, Virus Protease

Proteases/Proteasome, Microbiology/Virology, Metabolism, GPCR/G Protein, Immunology/Inflammation

233177

0.9971

C32H38N4O4S

574.73

CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)\C=C\S(=O)(=O)c1ccccc1

-20°C

Ice Packs

Small Compound