KAI-407 - CAS 1513879-18-9

KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM) . KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.

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Others

1513852

C22H14F3N5O

421.37

C(N(C)C1=CC=C(C#N)C=C1)(=O)C2=CN3C(=CN=C3C=N2)C4=CC=C(C(F)(F)F)C=C4

-20°C

Ice Packs

Small Compound