KBD4466 - CAS 3023713-87-0

KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-α. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE) . It is suitable for research into autoimmune diseases.

TLR, Interleukin, IFNAR

Immunology/Inflammation

3023626

C24H23F3N6O

468.47

C(F)(F)(F)[C@@]12[C@@](C1)(CN(C2)C=3C4=C(C(C#N)=CC3)N=CC=C4)C=5OC(=NN5)C6CCN(C)CC6

-20°C

Ice Packs

Small Compound