KCN1 - CAS 927823-01-6

KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE) -dependent manner. KCN1 potently inhibited the growth of subcutaneous malignant glioma tumor xenografts with minimal adverse effects on the host.

HIF/HIF Prolyl-Hydroxylase, Others, Histone Acetyltransferase

Chromatin/Epigenetic, Metabolism, Others

927823-01-6

C26H27NO5S

465.56

N(S(=O)(=O)C1=CC(OC)=C(OC)C=C1)(CC=2C=C3C(=CC2)OC(C)(C)C=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound