KD6001 - CAS 2983061-18-1

KD6001 is a humanized IgG1κ monoclonal antibody targeting CTLA4. It effectively disrupts the interaction between CTLA-4 and CD80 (IC50: 16 ng/mL) as well as CD86. KD6001 enhances the expression of IL-2 and IFNγ in PHA-activated human lymphocytes, demonstrating potent antitumor activity. It significantly inhibits tumor growth in mouse models with MC38, B16, and Hepa1-6 tumors. KD6001 is applicable in cancer research, including studies on advanced melanoma, hepatocellular carcinoma, and liver cancer.

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2983061-18-1

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Inhibitory Antibodies