KDX1381 - CAS 2757728-47-3

KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.

Casein Kinase

Stem Cells, Metabolism

2757678

C32H32F2N6O4S

634.7

O=C(C=1NC=2C=CC(F)=CC2C1C=3N=NN(C3)CC4CCN(CCNS(=O)(=O)C=5C=CC(=CC5)C=6C(F)=CC=CC6O)CC4)C

-20°C

Ice Packs

Small Compound