Keap1-Nrf2-IN-11 - CAS 2796292-75-4

Keap1-Nrf2-IN-11 (Compound 6k), a potent Keap1-Nrf2 inhibitor, exhibits a dissociation constant (KD) of 0.21 nM. It hampers the production of reactive oxygen species (ROS) and nitric oxide (NO), as well as the expression of tumor necrosis factor-alpha (TNF-α) . By promoting Nrf2 nuclear translocation, it mitigates inflammation and is utilized in anti-inflammatory studies [1].

Others, Nrf2, ROS Kinase, NO Synthase

Tyrosine Kinase/Adaptors, Others, Immunology/Inflammation

2796213

C36H43N7O8S2

765.9

CCN1CCN(CC1)CCC(=O)NC2=CC=C(C=C2)S(=O)(=O)N(CC(=O)N)C3=CC=C(C4=CC=CC=C43)N(CC(=O)N)S(=O)(=O)C5=CC=C(C=C5)OC

-20°C

Ice Packs

Small Compound