Keap1-Nrf2-IN-13 - CAS 2456294-92-9

Keap1-Nrf2-IN-13 is a potent inhibitor of the Keap1-Nrf2 protein-protein interaction (PPI) with an IC50 value of 0.15 μM, indicating high efficacy. It binds strongly to Keap1 by forming hydrogen bonds with critical polar residues (Asn414, Arg415, Arg483, Gln530), showcasing specificity. This compound has implications for research into diseases associated with oxidative stress and inflammation, such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), and cancers, due to its mechanism of action.

Others, Nrf2

Immunology/Inflammation, Others

2456193

C28H32N2O10S2

620.69

N(S(=O)(=O)C1=CC=C(OC)C=C1)(CC2=C(CN(S(=O)(=O)C3=CC=C(OC)C=C3)[C@H](C(O)=O)C)C=CC=C2)[C@H](C(O)=O)C

-20°C

Ice Packs

Small Compound