Keap1-Nrf2-IN-14 - CAS 1928782-31-3

Keap1-Nrf2-IN-14 is a KEAP1-NRF2 inhibitor that effectively disrupts the KEAP1-NRF2 interaction (IC50: 75 nM) with a Kd=24 nM for KEAP1. Keap1-Nrf2-IN-14 induces the expression of NRF2 target genes and is able to enhance downstream antioxidant and anti-inflammatory effects. -Nrf2-IN-14 can be used to study oxidative stress-related inflammation.

Reactive Oxygen Species, Others, Nrf2

Others, NF-κB, Metabolism, Immunology/Inflammation

1928748

C30H29NO8S

563.62

N(S(=O)(=O)C1=C(C)C=C(C)C=C1C)(CC(O)=O)C=2C3=C(C(OC(C(O)=O)C4=CC=C(OC)C=C4)=CC2)C=CC=C3

-20°C

Ice Packs

Small Compound