KH-4-43 - CAS 2813310-07-3

KH-4-43, an inhibitor of the E3 CRL4 ligase complex, demonstrates anticancer activity by targeting the core of the E3 CRL4. It exhibits a binding affinity (Kd) of 83 nM to the E3 ROC1-CUL4A CTD and 9.4 μM to the closely related ROC1-CUL1 CTD [1].

E1/E2/E3 Enzyme, Others

Others, Ubiquitination

2813310-07-3

C19H10ClF3N2O4

422.74

C(F)(F)(F)C1=C(C(=O)C=2C(O1)=C(O)C(O)=CC2)C3=CN(N=C3)C4=CC=C(Cl)C=C4

-20°C

Ice Packs

Small Compound