KI-TOX-A3 - CAS 1351116-34-1

KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 μM for the TOX-KAT7 interaction. It promotes proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses CD8+ T cell exhaustion, and inhibits proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 holds potential for research in hematological malignancies, including T-ALL.

Histone Acetyltransferase

Chromatin/Epigenetic

1351081

C18H13N3O3

319.31

N#CC1=C(N=C2C=3C=CC(O)=CC3CC2=C1C=4OC(=CC4)CO)N

-20°C

Ice Packs

Small Compound