Ki11502 - CAS 347155-76-4

Ki11502 is a multi-target receptor tyrosine kinase (RTK) inhibitor that selectively inhibits the activity of PDGFβ/α receptors (with an IC50 of less than 10 nM) . It specifically suppresses PDGFβ receptor phosphorylation, proliferation, and proteoglycan synthesis in human vascular smooth muscle cells. Additionally, Ki11502 induces apoptosis and exhibits significant antiproliferative effects against specific leukemia subgroups, including those with Imatinib-resistant mutations. It is particularly suitable for studying the role of PDGF in vascular diseases and the involvement of proteoglycans in atherosclerosis.

Akt, Bcl-2 Family, Apoptosis, FLT, PERK, PDGFR

Cytoskeletal Signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling

347075

C26H23N3O4S

473.54

O=C(NC(=S)NC1=CC=C(OC=2C=CN=C3C=C(OC)C(OC)=CC32)C=C1)C=4C=CC=CC4C

-20°C

Ice Packs

Small Compound