KIM-161 - CAS 2559686-28-9

KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 μM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.

PI3K, Reactive Oxygen Species, Akt, Apoptosis, mTOR

NF-κB, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Apoptosis, Metabolism

2559649

C27H25N3O3

439.51

O=C\1N(C(C)=N/C1=C\C2=CC=C(OC)C=C2)C3=CC=C(CC(NCC4=CC=CC=C4)=O)C=C3

-20°C

Ice Packs

Small Compound