KIN-8194 - CAS 330786-01-1

KIN-8194 is a dual inhibitor of HCK and BTK, effective when administered orally, displaying IC 50 values of 0.915 nM for HCK and <0.495 nM for BTK. It inhibits growth and disrupts integrin-mediated adhesion in BTKi-resistant mantle cell lymphoma (MCL) . Additionally, KIN-8194 has shown efficacy in overcoming ibrutinib resistance, enhancing survival in TMD-8 ABC DLBCL xenografted mice [1] [2].

BTK, Src

Angiogenesis, Tyrosine Kinase/Adaptors

330786-01-1

C28H33N7O

483.61

NC1=C2C(=NN(C2=NC=N1)[C@@H]3CC[C@H](CC3)N4CCN(C)CC4)C5=CC=C(OC6=CC=CC=C6)C=C5

-20°C

Ice Packs

Small Compound