KIN-8741 - CAS 2941104-53-4

KIN-8741 is a highly selective and orally active Type IIb c-Met inhibitor. It exhibits broad-spectrum activity against c-Met kinase mutations. KIN-8741 demonstrates antitumor activity in non-small cell lung cancer models with MET gene amplification and exon 14 deletion. It is applicable in research on c-Met-driven cancers, particularly advanced tumors harboring MET exon 14 skipping mutations and acquired resistance mutations.

C-Met/HGFR

Tyrosine Kinase/Adaptors

2941047

C26H23F2N3O6

511.47

O(C=1C2=C(C=C(OC)C(O[C@H](CO)C)=C2)N=CC1)C3=C(F)C=C(NC(=O)C=4C(OC)=CC=NC4)C=C3F

-20°C

Ice Packs

Small Compound