KL-50 - CAS 1161826-19-2

KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.

DNA/RNA Synthesis, Others

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others

1161805

C7H7FN6O2

226.17

O=C(N)C=1N=CN2C(=O)N(N=NC12)CCF

-20°C

Ice Packs

Small Compound